Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

AN Gale, MW Pavesic, TJ Nickels, Z Xu, BP Cormack… - Msphere, 2023 - Am Soc Microbiol
… of many 60S ribosomal proteins also activated Pdr1, thus mimicking the effects of the mRNA
… results of genome-wide screens for genes influencing fluconazole resistance in pdr1∆ and …

[HTML][HTML] Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory …

LN Balarezo-Cisneros, S Parker, MG Fraczek… - PLoS …, 2021 - journals.plos.org
… data we analysed the genome-wide dysregulation of protein … share a TF-binding motif
recognised by Pdr1 and Pdr3 [56]. In the S… of transcriptional activation in multidrug resistance …

[HTML][HTML] Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

S Ottilie, MR Luth, E Hellemann, GM Goldgof… - Communications …, 2022 - nature.com
… CRISPR-based, genome-wide knockout and knockdown … Recently, a selection with rapamycin
in a pdr1 deletion strain of … SNVs lead to constitutive transcriptional activation of its target …

Evidence that ergosterol biosynthesis modulates activity of the Pdr1 transcription factor in Candida glabrata

BG Vu, GH Thomas, WS Moye-Rowley - MBio, 2019 - Am Soc Microbiol
… that azole drugs can directly bind to and stimulate activity of Pdr1 in this yeast (13). … The
camphor promoter (camP), which included ScADH1 terminator followed by the multiple copies of …

Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and widespread in trans effects on the protein regulatory …

LN Balarezo-Cisneros, S Parker, MG Fraczek… - bioRxiv, 2020 - biorxiv.org
… data we analysed the genome-wide dysregulation of protein … a TF-binding motif recognized
by Pdr1 and Pdr3 [45]. In the S… that acts predominantly as a transcriptional activator [44, 47, 48…

[HTML][HTML] Functional information from clinically-derived drug resistant forms of the Candida glabrata Pdr1 transcription factor

L Simonicova, WS Moye-Rowley - PLoS genetics, 2020 - journals.plos.org
… The pathogenic yeast Candida glabrata acquires resistance … forms of Pdr1 have elevated
transcriptional activation, we … with a PCR fragment containing three copies of human influenza …

Comprehensive profiling of the fission yeast transcription start site activity during stress and media response

M Thodberg, A Thieffry, J Bornholdt, M Boyd… - Nucleic acids …, 2019 - academic.oup.com
… However, comprehensive genome-wide maps of TSSs and … To this end, we profiled TSS
activity genome-wide in S. pombe … For example, YES up were enriched for a PDR1 motif and a …

Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces (Candida) glabrata via a novel CRISPR activation system

L Maroc, H Shaker, RS Shapiro - Msphere, 2024 - Am Soc Microbiol
… a diversity of transcriptional activators to achieve robust gene … been applied in fungal pathogens
and other fungal species. In C. … were due to transcriptional overexpression of PDR1, we …

Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing

S Ottilie, MR Luth, E Hellemann, GM Goldgof, E Vigil… - bioRxiv, 2021 - biorxiv.org
… CRISPR-based, genome-wide knockout and knockdown … SNVs lead to constitutive
transcriptional activation of their target … PDR3, a new yeast regulatory gene, is homologous to …

[HTML][HTML] Quantitative trait nucleotides impacting the technological performances of industrial Saccharomyces cerevisiae strains

E Peltier, A Friedrich, J Schacherer, P Marullo - Frontiers in Genetics, 2019 - frontiersin.org
… would be undetectable by genome-wide association studies (… the technological properties
of industrial yeast strains. … , different alleles of the transcriptional factors PDR1 (M308I) and …